The implementation of strategies and actions to reduce social, economic and environmental health risks and vulnerabilities due to the climate crisis was possible in Antioquia because of the declaration of the emergency in the territory. In the formulation process, 4 major components were identified, a baseline or diagnosis, a vulnerability analysis, a strategic component to act against these problems and the transversally to the previous components thorugh a participation, dissemination and public communication mechanism. Some important findings at the departmental level have to do with low institutional capacities in environmental health at the municipal level. It was identified how certain productive sectors (mining, agriculture and construction) increase the impacts on water, air and soil, increasing the probability of further damage in the face of the growing increase in extreme weather events such as fires, windstorms and floods, and increasing in turn the rates of morbidity and mortality from related diseases. Thus, the need for promotion and prevention programs in environmental health is evident to reduce the effects on health due to the effects of climate change. 45 adaptation strategies were formulated with short, medium and long-term actions, where strategies that provide mitigation co-benefits stand out, others are those based on socio-ecosystems and communities, or on the improvement of basic infrastructure and development sectors, coordination with risk management and those that promote the strengthening of institutional and community capacities. They were held many roundtalbels with the participation of more than 1,200 people, where the participating actors recognized the effects of climate change related them to health. This has been an opportunity to recognize that health must be transversal in all policies, which strengthens intersectoral and transectoral dialogue and synergies can be generated in resources, not only financial, but also human and technical knowledge